High Resolution GC/MS Analysis of Ginkgolic Acids in Ginkgo biloba Plants, Extracts, and Dietary Supplements Using the Agilent 5975C Series GC/MSD Authors
نویسندگان
چکیده
A high-resolution GC/MS method using the Agilent 7890 GC and the Agilent 5975C Series GC/MSD has been developed and validated for the analysis of potentially harmful ginkgolic acid (GA) species that is superior to current HPLC methods. Ozonolysis was used to identify the position of double bonds in four different unsaturated GA isomers. The 15:1 isomer was dominant in all the plant samples, and the ratio of D10 to D8 GA15:1 can be used to determine the Ginkgo biloba plant part (seed or leaf) source of the GAs present in commercial dietary supplements and other ginkgo products.
منابع مشابه
Comparative analysis of pharmaceuticals and dietary supplements containing extracts from the leaves of Ginkgo biloba L.
Abstract: Chromatography (TLC and HPLC) tests were performed of 11 preparations containing dry extract of Ginkgo biloba leaves: three pharmaceuticals (preparations 1, 3 and 5) and eight dietary supplements (preparations 2, 4, 6-11), and dry extract of Ginkgo biloba leaves (preparation 12) as a standard certified for compliance with Eur. Ph. 6.1. and FP VIII (1, 2). Preparations registered in Po...
متن کاملToxicology Screening of Whole Blood Extracts Using GC/Triple Quadrupole/MS
The Agilent 7000 GC/QQQ system can provide both high selectivity and high sensitivity for the analysis of drugs. Low-level detection and confirmation of large numbers of target drugs in blood extracts is possible in a single run. Combined with information from a single quadrupole screening instrument like the Agilent GC/NPD/MSD/DRS system, a much more complete picture of each sample is now poss...
متن کاملDetermination of Phthalate Concentration in Toys and Children’s Products
Due to public health concerns, the Chinese government and the US Consumer Product Safety Commission (CPSC) both introduced test methods for the analysis of phthalate content in childcare items and toys using GC/MS in 2008. These regulatory methods require determination of the presence of six regulated phthalate esters including dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylh...
متن کاملLongterm Detection of Anabolic Steroid Metabolites in Urine
A method for the longterm detection of anabolic steroid metabolites in urine was developed using both the Agilent 6890N network GC system with an Agilent 5975B Series GC/MSD and the Agilent 7000 Series Triple Quadrupole GC/MS. Monitoring the sulfate conjugates of these metabolites, instead of the routine glucuronide metabolites allowed detection of methenolone for a post-administration period t...
متن کاملEnhanced Essential Oils Analysis Using a High Performance Benchtop GC/MS System Application Note
A gas chromatograph (GC) coupled with a mass spectrometer (MS) forms a powerful tool for high quality quantitative and qualitative analysis. However, GC/MS analysis of complex mixtures such as essential oils often is a time-consuming task due to limitations in techniques and instrumentation. Faster analyses of these mixtures are possible by coupling the 5973A mass selective detector (MSD) with ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015